Kaplan-Meier survival assessment of the patients with opioid drug poisoning complicated by acute kidney damage

RESUME. Despite the fact that opioids do not have direct nephrotoxicity, a significant overdose, or their combination with alcohol and other psychotropic substances, contributes to development of critical changes in many organs systems body, which leads, particular, acute kidney injury (AKI). Aim. Using comparative analysis Kaplan-Meier method, investigate survival rates patients opioid drug poisoning complicated by respiratory distress syndrome treated hemodialysis. Materials Methods. A cohort retrospective medical data 128 (107 men, 21 women) aged 18 39 years who received treatment intensive care extracorporeal detoxification department "Kyiv City Emergency Hospital" period 2017–2021 diagnosis "Acute poisoning" (МКХ-10:Т40.0-Т40.3), renal failure. Statistical study results was performed using estimate; p≤0.05; statistical application package from Microsoft Excel 2019 used. Results. graphs indicated AKI due morphine, heroin, methadone statistically difference (p < 0.05). The highest were shown morphine (100 %), lowest groups (82.7 %) heroin (48.3 %). curves showed all deaths occurred within 3–18 days starting treatment, most (90 occurring 3–12 days. Cumulative among methadone-induced stratified blood content where detected, rate 100 %, combined it 75.2 %. Conclusions. similarity clinical picture natural synthetic (opioid syndrome), causes its course differ different drugs. Survival are adversely affected presence blood. Key Words: poisoning,